论文部分内容阅读
目的:观察腹腔感染病人肠黏膜通透性的变化,了解腹腔感染对肠黏膜屏障功能的影响。方法:将20例病人在确诊腹腔感染24h内测定肠道乳果糖与甘露醇吸收比值(L/M)、血清内毒素和肿瘤坏死因子α(TNF-α)水平,并同期采集病情严重度(APACHEⅡ评分和SOFA评分)、ICU滞留时间、住院时间和病情转归等。结果:腹腔感染组LMR水平较正常组明显升高(P<0.01);血清内毒素和TNF-α水平与LMR间呈显著正相关(P<0.01,P<0.05);肠黏膜通透性与病人病情严重程度有显著相关性(P<0.01);腹腔感染病人肠黏膜通透性变化程度与病死率也有明显相关性(P<0.05)。结论:腹腔感染病人的肠黏膜通透性显著增加,腹腔感染可导致肠黏膜屏障功能损害。
Objective: To observe the changes of intestinal mucosal permeability in patients with abdominal infection and to understand the influence of abdominal infection on intestinal mucosal barrier function. Methods: Twenty patients were tested for intestinal lactulose and mannitol absorption ratio (L / M), serum endotoxin and tumor necrosis factor α (TNF-α) levels within 24 hours after diagnosis of intraperitoneal infection, and the severity of the disease APACHE Ⅱ score and SOFA score), ICU residence time, hospital stay and illness prognosis. Results: The level of LMR in abdominal infection group was significantly higher than that in normal group (P <0.01). The levels of serum endotoxin and TNF-α were positively correlated with LMR (P <0.01, P <0.05) There was a significant correlation between the severity of illness and the severity of illness (P <0.01). The changes of intestinal mucosal permeability and mortality in patients with abdominal infection were also significantly correlated (P <0.05). Conclusion: The intestinal mucosa permeability increased significantly in patients with abdominal infection, abdominal infection can lead to intestinal mucosal barrier dysfunction.