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1942年Lansteiner及Chase二人实验证明,迟发性变态反应可由活的白细胞被动转移而不能由免疫血清转移,建立了细胞免疫的概念。此后,Lawrence于1949及1952年先后从对结核菌素及链球菌抗原有免疫反应的供者白细胞,将迟发性变态反应转移给无免疫反应的受者,而后发现此反应用致敏者的淋巴细胞经蒸馏水溶解或冻溶后的提取物也可转移成功,并且证明再从受者的白细胞提取物还能引起第二个受者皮试阳转。为表达其生物活性及代表小分子量可透析物,1955年定名为转移因子(简称TF)。
In 1942 Lansteiner and Chase two experiments show that delayed allergic reaction by passive transfer of living white blood cells can not be immune serum transfer, established the concept of cellular immunity. Since then, Lawrence in 1949 and 1952 successively from the donor leukocytes immune reaction to tuberculin and streptococcal antigen, the delayed allergic reaction was transferred to non-immune recipients, and found that the reaction with the sensitized Lymphocytes dissolved in lysed or lysed extracts were also successfully transfused, and the leukocyte extract from recipients was also found to cause a second recipient dermal test. To express its biological activity and on behalf of a small molecular weight dialyzate, 1955 named transfer factor (referred to as TF).