干燥综合征(Sjgren’s syndrome,SS)是以口干、眼干为突出表现的慢性自身免疫性疾病,病理特征为外分泌腺灶性淋巴细胞浸润。临床上可分为原发性SS(primary SS,pSS)和继发性SS(secondary SS,sSS),流行病学调查显示我国人群患病率约为0.29%~0.77%~([1])。约1/3的SS患者可出现肺间质纤维化、肺动脉高压、肾小管酸中毒、肝脏损害和神经系统受累等系统损害,且合并恶性淋巴瘤的概率明 Sjogren’s syndrome (SS) is a chronic autoimmune disease characterized by dry mouth and dry eye. Pathological features are exocrine focal lymphocyte infiltration. Clinically, it can be divided into primary SS (SS) and secondary SS (SSS). Epidemiological survey shows that the prevalence in Chinese population is about 0.29% ~ 0.77% ~ ([1]) . About 1/3 of SS patients may appear interstitial fibrosis, pulmonary hypertension, renal tubular acidosis, liver damage and nervous system involvement and other system damage, and the probability of malignant lymphoma