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目的:探讨PELF方案治疗晚期胃癌的临床疗效和毒副反应。方法:应用PELF方案:顺铂(PDD)→亚叶酸钙(CF)→依托泊苷(VP16)→氟尿嘧啶(5蛳Fu),每28 d 1周期,至少连用2个周期后评定近期疗效和毒副反应。结果:完全缓解(CR)9.5 %(7/74),部分缓解率(PR)52.7 %(39/74),总有效率(RR)62.2 %(46/74)。毒副反应主要为骨髓抑制和消化道反应,均可耐受。结论:PELF方案治疗晚期胃癌为较有效的化疗方案。
Objective: To investigate the clinical efficacy and side effects of PELF regimen in the treatment of advanced gastric cancer. Methods: The PELF regimen: PDD, CF, VP16 and Fluorouracil (5 蛳 Fu) were given every 28 d for at least 2 cycles to evaluate the short-term efficacy and toxicity side effects. Results: Complete response (CR) 9.5% (7/74), partial response rate (PR) 52.7% (39/74) and total effective rate (RR) 62.2% (46/74). Toxic side effects mainly for bone marrow suppression and gastrointestinal reactions, can be tolerated. Conclusion: PELF regimen is an effective chemotherapy regimen for advanced gastric cancer.