组织激肽释放酶-激肽系统(KKS)广泛存在于动物体的各种组织中,通过多条信号通路产生多种生物学作用,参与多器官功能调节和多种病理生理过程,如心血管、肾脏和神经系统的调节,细胞增殖、炎症、凋亡等过程。1 KKS的组成和生物学活性KKS的组成包括激肽释放酶原、激肽释放酶(KLK)、激肽原、激肽和激肽受体。组织中存在的激肽释放酶原活化后成为激肽释放酶。激肽释放酶分为两种类型:组织激肽释放酶和血 Tissue kallikrein-kinin system (KKS) widely exists in various tissues of animals and produces a variety of biological effects through multiple signaling pathways and is involved in the regulation of multiple organ functions and various pathophysiological processes such as cardiovascular , Kidney and nervous system regulation, cell proliferation, inflammation, apoptosis and other processes. Composition and Biological Activity of KKS KKS consists of kallikrein, kallikrein (KLK), kininogen, kinin and kinin receptors. Kallikrein, which is present in tissues, becomes a kallikrein upon activation. Kallikrein is divided into two types: tissue kallikrein and blood