卡马西平(carbamazepine,CBZ)是目前常用的一线抗癫痫药,尤其对于复杂部分性发作的癫痫具有显著的疗效。然而,部分患者对卡马西平异常敏感而容易出现药物过敏,严重者甚至出现危及生命的重型药疹,如中毒性表皮坏死松解症、Stevens-Johnson综合征等。90%以上的严重皮肤反应发生在 Carbamazepine (carbamazepine, CBZ) is the first-line antiepileptic drugs currently used, especially for the treatment of epilepsy complicated by partial seizures. However, some patients are extremely sensitive to carbamazepine and are susceptible to drug allergies. In some cases, even serious life-threatening drug eruptions such as toxic epidermal necrolysis, Stevens-Johnson syndrome and the like occur. More than 90% of severe skin reactions occur