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目的 :观察机体在不同代谢状况下对缺氧耐受性的影响 ,并对其影响因素进行探讨。方法 :腹腔注射咖啡因、氯丙嗪 ,复制高代谢状态和低代谢状态的小白鼠模型 ,用氧电极法测定剩余氧浓度 ,分别计算动物存活时间、动物总耗氧量和代谢耗氧率。以腹腔注射生理盐水鼠作为对照组。结果 :与对照组比较 ,高代谢状态组小白鼠的存活时间明显缩短 ,机体的代谢耗氧率显著增加 ,剩余氧浓度则增高 ,总耗氧量降低 ;低代谢状态组存活时间延长 ,机体的代谢耗氧率显著降低 ,剩余氧浓度明显增加 ,总耗氧量减少。结论 :机体高代谢状态时 ,对缺氧的耐受性降低 ,存活时间缩短 ;反之 ,在低代谢状态时对缺氧的耐受性增强 ,存活时间延长。但是过度抑制时 ,机体对氧的利用能力反而有所下降。
OBJECTIVE: To observe the effect of body metabolism on hypoxia tolerance and to explore its influencing factors. Methods: Intraperitoneal injection of caffeine, chlorpromazine, replication of high metabolism and low metabolism of the mouse model, measured by oxygen electrode residual oxygen concentration, were calculated animal survival time, animal total oxygen consumption and metabolic oxygen consumption rate. The rats were injected intraperitoneally with saline as the control group. Results: Compared with the control group, the survival time of mice in high metabolism group was significantly shortened, the body’s metabolic oxygen consumption rate increased significantly, the residual oxygen concentration increased, the total oxygen consumption decreased; the survival time in low metabolic state group prolonged, Metabolic oxygen consumption rate was significantly reduced, the remaining oxygen concentration increased significantly, total oxygen consumption decreased. CONCLUSION: When the body is in a high metabolic state, its tolerance to hypoxia is reduced and the survival time is shortened. On the contrary, its tolerance to hypoxia is enhanced and the survival time is prolonged in a low metabolic state. However, excessive inhibition, the body’s ability to use oxygen but declined.