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观察了２６例非胰岛素依赖性糖尿病（ＮＩＤＤＭ）肾病患者肾小管间质病变的特点，包括肾小管功能的改变、肾组织形态学改变及部分患者的尿表皮生长因子（ＥＧＦ）。结果发现：１．ＮＩＤＤＭ肾病小管间质功能受损较为弥漫，既有近端肾小管细胞损伤，也有远端小管的损伤；在形态学上表现为肾小管萎缩、基底膜增厚、间质扩张、弥漫炎细胞浸润及不同程度的纤维化。２．在肾小球滤过功能明显受损之前，小管间质病变即已出现，并随着肾功能的恶化而逐步加重。提示小管间质损害在糖尿病肾病（ＤＮ）的发生发展中起着与小球病变同样重要的作用。
The characteristics of tubulointerstitial lesions in 26 patients with non-insulin dependent diabetic nephropathy were observed, including changes in renal tubular function, renal morphological changes and urinary epidermal growth factor (EGF) in some patients. The results showed that: 1. NIDDM nephropathy tubulointerstitial damage is more diffuse, both proximal tubular cell damage, but also distal tubule damage; morphological manifestations of tubular atrophy, basement membrane thickening, interstitial expansion, diffuse inflammatory cell infiltration And different degrees of fibrosis. 2. Before the glomerular filtration function was significantly impaired, tubulointerstitial lesions have emerged, and with the deterioration of renal function and gradually increased. Tip tubulointerstitial damage in the occurrence and development of diabetic nephropathy (DN) plays the same important role and glomerular lesions.