儿童混合性结缔组织病(MCTD)在小儿风湿免疫疾病中非常少见,1972年Sharp[1]首先报道了一组25例伴有系统性硬化症、系统性红斑狼疮(SLE)、多发性肌炎的多种结缔组织病的重叠综合征,同时伴有高滴度可提取抗核糖核蛋白抗体,即抗U1RNP抗体阳性为特征的一组综合征,并命名为MCTD。近3 Mixed childhood connective tissue disease (MCTD) is very rare in children with rheumatoid immune disease, Sharp [1] first reported in 1972 a group of 25 patients with systemic sclerosis, systemic lupus erythematosus (SLE), polymyositis Of overlapping syndromes of connective tissue disease, accompanied by a high titers of anti-ribonucleoprotein antibodies, anti-U1RNP positive antibodies characterized by a group of syndromes, and named MCTD. Nearly 3