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目的:观察不同给药途径下四君子汤对窒息后喂养不耐受新生儿血浆胃动素(MTL)的影响。方法:将78例窒息后喂养不耐受新生儿随机分为四君子汤经胃管微量给药组、四君子汤微量灌肠给药组及常规静脉高营养形式喂养的对照组各26例,分别施以四君子汤微量喂养、四君子汤微量灌肠及常规静脉高营养形式喂养,检测治疗前及治疗第1、3、4天患儿血浆MTL的变化情况,并与正常新生儿MTL比较。结果:新生儿窒息后多在开奶后的24～72小时内出现喂养不耐受的症状,其血浆MTL水平显著低于正常新生儿(P<0.01),经加用四君子汤治疗后,其血浆MTL水平呈逐渐回升的趋势并渐趋于正常,其恢复情况明显优于对照组(P<0.01);四君子汤经胃管微量给药组与经肛管灌肠给药组患儿在治疗后的不同时间段内血浆MTL水平的动态变化没有统计学意义(P>0.05)。结论:在常规胃肠外营养的基础上加用四君子汤治疗喂养不耐受能够对胃肠道激素分泌水平恢复正常起到有效的促进作用,从而加速疾病的康复。同时,经灌肠给药的方式相比其他给药途径更为简便易行,具有良好的可操作性,有利于临床推广。
Objective: To observe the effects of different routes of administration of Sijunzi Decoction on plasma motilin (MTL) in infants after intoxication. Methods: Seventy-eight neonates with intolerance after feeding asphyxia were randomly divided into Sijunzi Decoction, micro-enema administrated by Sijunzi Decoction, micro enema-administered group treated by Sijunzi Decoction, and control group fed by conventional intravenous hypernutrition. Sijunzi Decoction, Sijunzi Decoction and conventional intravenous hypernutrition. The changes of plasma MTL in children before and after treatment for 1, 3 and 4 days were detected and compared with the normal neonatal MTL. Results: After neonatal asphyxia, the symptoms of feeding intolerance appeared within 24 ~ 72 hours after the milk was opened, the plasma MTL level was significantly lower than that of the normal newborns (P <0.01). After adding Sijunzi Decoction, The level of plasma MTL gradually rose back to normal and the recovery was significantly better than that of the control group (P <0.01). After treatment with Sijunzi Decoction by gastric tube micro-administration group and anal canal enema-administered group The dynamic changes of plasma MTL levels in different time periods were not statistically significant (P> 0.05). CONCLUSION: Adding Sijunzi Decoction to feeding intolerance can effectively promote the secretion of gastrointestinal tract hormones and promote the recovery of the disease on the basis of routine parenteral nutrition. At the same time, the way of enema administration compared to other routes of administration is more simple and easy, has good maneuverability, is conducive to clinical promotion.