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目的观察右美托咪定对结直肠癌手术后早期认知功能障碍的影响。方法将86例结直肠癌患者随机平均分组,对照组43例于手术前、术中持续静脉滴注生理盐水,观察组43例于麻醉诱导前静脉给予右美托咪定0.5μg/kg,10min泵注完毕后以0.4μg/(kg·h)维持,在术前、术后利用简易精神状态量表MMSE评估二组内及组间病例的早期认知功能障碍的发生情况。结果观察组术前、术后MMSE评分变化不显著(P>0.05),而对照组术后1d、3d MMSE评分与术前明显比较降低(P<0.05),术后1d、3d观察组认知功能障碍程度明显轻于对照组(P<0.05);术后3d观察组认知功能障碍总发生率与对照组比较差异有统计学意义(P<0.05)。结论右美托咪定能够有效降低并预防结直肠癌患者术后早期认知功能障碍的发生率及其发病程度。
Objective To observe the effect of dexmedetomidine on early cognitive dysfunction after colorectal cancer surgery. Methods A total of 86 patients with colorectal cancer were randomly divided into control group (n = 43) and control group (n = 43). The control group received continuous intravenous infusion of normal saline during the operation and 43 patients in the observation group received intravenous dexmedetomidine 0.5 μg / kg After the injection, the patients were maintained at 0.4μg / (kg · h), and MMSE was used to evaluate the early cognitive dysfunction in the two groups and between groups before and after the operation. Results The MMSE score of the observation group before and after operation was not significantly different (P> 0.05), while the MMSE score of the control group was significantly lower than that before operation on the 1st and 3rd postoperative day (P <0.05), and on the 1st and 3rd postoperative day The degree of dysfunction was significantly lower than that of the control group (P <0.05). The total incidence of cognitive dysfunction in the observation group after 3 days was significantly different from that in the control group (P <0.05). Conclusion Dexmedetomidine can effectively reduce and prevent the incidence of postoperative early cognitive dysfunction and its incidence in patients with colorectal cancer.