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目的观察缬沙坦治疗急性心肌梗死合并阵发性心房颤动的疗效。方法选择急性心肌梗死合并阵发性心房颤动患者,随机分为治疗组,对照组。治疗组根据血压水平给予缬沙坦口服(40~160 mg,每日1次),长期用药。对照组未服。患者门诊随访12个月,定期以心电图、动态心电图检查。结果阵发性房颤再发率:治疗组4例(12.5%),明显低于对照组7例(25%),经统计学比较(P<0.05)。转为持续性或永久性房颤的发生率:治疗组2例(4.5%),明显低于对照组4例(13%)经统计学比较P<0.05。缺血事件的发生率:治疗组7例(21%),明显低于对照组12例(42%),经统计学比较P<0.05。结论缬沙坦治疗急性心肌梗塞合并房颤的患者,不但能使心衰及冠心病恶化等缺血事件明显减少,而且能够降低阵发性房颤的复发率,减少持续性及永久性房颤的发生率。
Objective To observe the effect of valsartan on acute myocardial infarction complicated with paroxysmal atrial fibrillation. Methods Acute myocardial infarction patients with paroxysmal atrial fibrillation were randomly divided into treatment group and control group. The treatment group was given valsartan orally (40 to 160 mg once daily) according to the blood pressure level for long-term use. The control group was not served. Patient outpatient follow-up of 12 months, regular ECG, Holter examination. Results The recurrence rate of paroxysmal atrial fibrillation was 4 cases (12.5%) in the treatment group, which was significantly lower than that in the control group (7 cases, 25%). The difference was statistically significant (P <0.05). The incidence of persistent or permanent atrial fibrillation was 2 cases (4.5%) in the treatment group, which was significantly lower than that in the control group (13%) (P <0.05). Incidence of ischemic events: 7 cases (21%) in the treatment group were significantly lower than those in the control group (42%), P <0.05 by statistical analysis. Conclusion Valsartan in patients with acute myocardial infarction complicated by atrial fibrillation can not only significantly reduce ischemic events such as heart failure and coronary heart disease, but also reduce the recurrence rate of paroxysmal atrial fibrillation and reduce persistent and permanent atrial fibrillation The incidence of.