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目的:观察大鼠HE染色的卵巢组织病理形态变化,为复方中药治疗PCOS模型大鼠提供初步实验依据。方法:用Poresky法诱导多囊卵巢综合征大鼠,并分别以中药、西药(罗格列酮)、中西药联合治疗,观察大鼠卵巢重量、面积的变化及卵巢大体解剖及卵泡形态的改变,探讨几种不同情况下的大鼠卵巢形态学的变化。结果:复方中药能降低卵巢重量及卵巢平均面积,增加卵泡壁颗粒细胞层及黄体数量。结论:复方中药能改善PCO的情况和促进卵巢排卵功能的部分恢复。
OBJECTIVE: To observe the histopathological changes of ovarian tissue stained with HE in rats, and to provide preliminary experimental evidence for the treatment of PCOS model rats with compound Chinese herbs. METHODS: The Poresky method was used to induce PCOS rats. The rats were treated with traditional Chinese medicine, Western medicine (Rosiglitazone) and Chinese and Western medicine respectively. The changes of ovarian weight, area, gross anatomy of the ovary and changes of follicular morphology were observed. Investigate changes in rat ovary morphology under several different conditions. Results: Compound Chinese herbs can reduce the weight of ovary and the average area of ovary, and increase the number of granular cell layers and corpus luteum in the follicular wall. Conclusion: Compound Chinese herbs can improve the status of PCO and promote partial recovery of ovarian function.