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目的观察肺心病心衰期患者血浆内皮素(ET1)浓度,与1组同龄无心脏病患者血浆内皮素含量对照,探讨ET1是否参与肺心病肺动脉高压心衰的病理过程。方法用放射免疫法测定30例肺心病患者心衰期血浆ET1浓度。结果肺心病心衰期血浆ET1浓度明显高于对照组。结论ET1参与肺心病肺动脉高压心衰病理过程。
Objective To observe the plasma concentration of endothelin (ET1) in patients with cor pulmonale with heart failure, and to compare the plasma endothelin level of the same age group without heart disease. To explore whether ET1 is involved in the pathogenesis of pulmonary heart failure with pulmonary heart disease. Methods Radioimmunoassay was used to determine plasma endothelin concentration in 30 patients with pulmonary heart disease. Results Pulmonary heart disease plasma ET1 concentration was significantly higher than the control group. Conclusion ET1 participates in the pathogenesis of pulmonary heart failure due to pulmonary heart disease.