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快动眼期睡眠行为障碍(RBD)是以REM期睡眠肌肉失张力的消失、伴随梦境发生的暴力行为等为特点,患者常会伤及他人和自身。RBD与帕金森病(PD)密切相关,伴有RBD的PD与不伴有RBD的PD有着不同的发病模式。在少动-强直型PD患者,RBD可在PD典型症状出现之前发生。RBD在经颅脑超声信号、脑电图、脑血流灌注、多巴胺代谢等方面的异常表现越来越支持RBD可能是PD发病的一个阶段。多数患者对氯硝西泮治疗有效。
Rapid Eye Movement Sleep Disorder (RBD) is characterized by the loss of muscle tone during REM sleep and the violent behavior associated with dreams. Patients often hurt others and themselves. RBD is closely related to Parkinson’s disease (PD). PD with RBD and PD without RBD have different patterns of morbidity. RBD can occur before the onset of typical PD symptoms in patients with less-than-atypical PD. RBD in the transcranial ultrasound signals, EEG, cerebral perfusion, dopamine metabolism and other abnormal performance more and more support for RBD may be a stage of PD. Most patients with clonazepam treatment effective.