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重症肌无力的发病机制目前尚不清楚,其中对HLA基因多态性与重症肌无力遗传易感性之间的关系进行了大量研究。不同种族、性别的重症肌无力病人遗传易感性与HLA-Ⅰ、Ⅱ、Ⅲ类基因各不同位点之间存在显著相关性,其易感机制有待于进一步阐明。
The pathogenesis of myasthenia gravis is not clear at present, in which the genetic polymorphism of HLA and the relationship between the genetic susceptibility to myasthenia gravis have been extensively studied. The genetic susceptibility of patients with myasthenia gravis of different races and genders has significant correlation with the different loci of HLA-Ⅰ, Ⅱ and Ⅲ genes, and the susceptibility mechanism needs to be further elucidated.