目的观察肝癌患者肝切除后血浆MMP-2和TIMP-2浓度变化及生长抑素干预。方法20例肝癌切除患者随机分成2组,常规治疗组和生长抑素治疗组,每组各10例,生长抑素治疗组给于生长抑素治疗。结果肝切除后,血浆MMP-2浓度明显上升,血浆TIMP-2浓度明显下降,应用SST能降低MMP-2浓底,升高TIMP-2浓度。结论原发性肝癌肝切除后应用SST可能对抑制肿瘤复发有实裨益 Objective To observe the changes of plasma MMP-2 and TIMP-2 levels and the intervention of somatostatin in patients with liver cancer after hepatectomy. Methods Twenty patients with hepatocellular carcinoma (HCC) were randomly divided into two groups: the conventional treatment group and the somatostatin treatment group, with 10 in each group. The somatostatin treatment group was given somatostatin treatment. Results After hepatectomy, the concentration of plasma MMP-2 increased significantly and the concentration of plasma TIMP-2 decreased significantly. SST decreased the concentration of MMP-2 and increased the concentration of TIMP-2. Conclusion The application of SST after hepatectomy for primary liver cancer may have practical benefits in inhibiting tumor recurrence