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目的探讨卡培他滨片辅助治疗老年晚期胃癌的临床疗效。方法选取2012年1月—2014年1月濮阳市红十字医院收治的老年晚期胃癌患者80例,随机分为观察组与对照组,各40例。对照组患者予以综合化疗,观察组患者在对照组基础上予以卡培他滨辅助治疗。观察两组患者临床疗效及毒副作用(消化道反应、血液学毒性、周围神经感觉障碍)发生情况。结果观察组患者总有效率高于对照组,差异有统计学意义(P<0.05);两组患者毒副作用发生率比较,差异无统计学意义(P>0.05)。结论卡培他滨片辅助治疗老年晚期胃癌的临床疗效显著,且毒副作用小。
Objective To investigate the clinical efficacy of capecitabine in adjuvant treatment of elderly patients with advanced gastric cancer. Methods From January 2012 to January 2014, 80 elderly patients with advanced gastric cancer admitted to Puyang Red Cross Hospital were randomly divided into observation group and control group, 40 cases in each group. The patients in the control group were given chemotherapy. The patients in the observation group were treated with capecitabine on the basis of the control group. Clinical efficacy and side effects (gastrointestinal reactions, hematologic toxicity, peripheral nerve sensory disturbances) in two groups were observed. Results The total effective rate of observation group was higher than that of control group, the difference was statistically significant (P <0.05). There was no significant difference between the two groups in the incidence of toxic and side effects (P> 0.05). Conclusion Capecitabine tablets adjuvant treatment of advanced gastric cancer in the clinical efficacy was significant, and the side effects of small.