目的了解济南市长清区手足口病流行病学特征,为制订防控措施提供科学依据。方法对2010~2012年济南市长清区手足口病资料进行分析。结果 2010~2012年济南市长清区共报告手足口病2 620例,年均发病率为155.87/10万。手足口病发病率,各年分别为187.30/10万、148.50/10万、130.65/10万(P<0.01);城乡结合部为196.22/10万,农村地区为91.09/10万(P<0.01);男性为191.51/10万,女性为120.08/10万(P<0.01)。2 620例中,5~8月占82.56%;1~3岁儿童占68.70%,散居儿童占60.53%,托幼儿童占35.19%。2010~2012年合计检测粪便标本210份,病毒核酸阳性的163份,阳性率为77.62%,其中CoxA16阳性率为40.95%,EV71阳性率为26.67%,其他肠道病毒阳性率10.00%。结论济南市长清区手足口病的发病存在明显的季节、地区、年龄差异,EV71和CoxA16交替流行。 Objective To understand the epidemiological characteristics of hand-foot-mouth disease in Changqing District of Jinan City and provide a scientific basis for making prevention and control measures. Methods The data of HFMD in Changqing District of Jinan City from 2010 to 2012 were analyzed. Results A total of 2 620 hand-foot-mouth disease cases were reported in Changqing District of Jinan City from 2010 to 2012, with an average annual incidence of 155.87 / 100 000. The incidence of hand-foot-mouth disease was 187.30 / lakh, 148.50 / lakh and 130.65 / lakh respectively in each year (P <0.01), 196.22 / lakh in rural-urban areas and 91.09 / lakh in rural areas ); 191.51 / 100,000 men and 120.08 / 100000 women (P <0.01). Among 2 620 cases, 82.56% were from May to August; 68.70% were from 1 to 3 years old, 60.53% were from scattered children and 35.19% from child care children. From 2010 to 2012, 210 positive stool samples and 163 positive virus nucleic acids were detected, the positive rate was 77.62%. The positive rate of CoxA16 was 40.95%, the positive rate of EV71 was 26.67%, and the positive rate of other enterovirus was 10.00%. Conclusion The incidence of HFMD in Changqing District of Jinan City has obvious seasonal, regional and age differences, and EV71 and CoxA16 are alternately prevalence.