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目的 :探讨p16蛋白表达与骨巨细胞瘤发生的关系。方法 :采用免疫组织化学S P法检测 4 2例骨巨细胞瘤的p16蛋白表达。结果 :骨巨细胞瘤的p16蛋白表达缺失率为 6 6 .7% ,p16蛋白表达随骨巨细胞瘤恶性程度的上升而降低。骨巨细胞瘤的多核巨细胞有 3种染色状态。结论 :p16蛋白表达降低与骨巨细胞瘤的发生有关 ,骨巨细胞瘤的多核巨细胞可能存在不同种类。
Objective: To investigate the relationship between the expression of p16 protein and the occurrence of giant cell tumor of bone. Methods: The expression of p16 protein in 42 cases of giant cell tumor of bone was detected by immunohistochemical SP method. Results: The loss of p16 protein in giant cell tumor of bone was 66.7%, the expression of p16 protein was decreased with the increase of malignant degree of giant cell tumor of bone. Giant cell tumor of giant cell giant cell multinucleate have three kinds of staining. Conclusion: The decreased expression of p16 protein is associated with the occurrence of giant cell tumor of bone. The giant cell tumor of giant cell tumor of bone may have different types.