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利用高脂饲料诱导的肥胖大鼠模型,研究了茶多酚通过调节过氧化物酶体增殖物激活受体防治肥胖症的机制.结果表明,茶多酚能够明显降低肥胖大鼠的体重、肝重及血清和肝脏甘油三酯的含量;同时,茶多酚在皮下和内脏白色脂肪组织中分别增高和降低过氧化物酶体增殖物激活受体的表达水平.另外,茶多酚可以上调皮下白色脂肪组织、内脏白色脂肪组织及褐色脂肪组织中过氧化物酶体增殖物激活受体的表达,并增加褐色脂肪组织中脂肪-氧化相关酶的表达.以上结果表明,茶多酚防治肥胖症的机制与其调节过氧化物酶体增殖物激活受体的相关通路有关.
The mechanism of tea polyphenols in preventing and treating obesity through regulating peroxisome proliferator-activated receptor was studied by using fat-induced obesity rat model.The results showed that tea polyphenols can significantly reduce the weight of obese rats, liver Weight and serum and liver triglyceride content; the same time, tea polyphenols in subcutaneous and visceral white adipose tissue increased and decreased peroxisome proliferator-activated receptor expression levels.In addition, tea polyphenols can be subcutaneous White adipose tissue, visceral white adipose tissue and brown adipose tissue, and increased the expression of fat-oxidation-related enzymes in brown adipose tissue.The above results show that tea polyphenols can prevent and treat obesity The mechanism of its regulation of peroxisome proliferator-activated receptor-related pathways.