目的评价加用巴曲酶治疗全频型突发性耳聋的临床疗效。方法对2009年1月-2011年6月耳鼻喉一科收治的全频下降型突发性耳聋患者83例(83耳),其中39例患者采用金纳多、甲钴胺、维生素B1等常规方法治疗,而另外44例患者在常规方法基础上加用巴曲酶治疗,两组治疗前后均进行纯音听阈及相关听力检查,并进行头颅及内听道核磁检查排除内听道及颅内占位性病变后,比较两组的治疗效果。结果治疗前两组患者的年龄、听力下降程度、相关因素等差异均无统计学意义(P>0.05),治疗后加用巴曲酶治疗组总有效率为88.6%,明显优于常规治疗组的总有效率(64.1%),差异有统计学意义(P<0.05)。结论常规治疗基础上加用巴曲酶溶栓治疗可缓解血管内血栓阻塞因素,对于全频型突发性耳聋有明显疗效,值得推广。 Objective To evaluate the clinical efficacy of Batroxobin in the treatment of full-range sudden deafness. Methods 83 patients (83 ears) with full-frequency descending sudden deafness admitted from January 2009 to June 2011 were enrolled in this study. 39 cases were treated with routine drugs such as Ginaton, mecobalamin and vitamin B1 Method, while the other 44 patients on the basis of conventional methods plus Batroxobin treatment, pure tone hearing threshold and related hearing tests were performed before and after treatment in both groups, and head and internal auditory canal magnetic resonance imaging to rule out the internal auditory canal and intracranial After bit lesions, the treatment effect was compared between the two groups. Results There was no significant difference in the age, hearing loss and related factors between the two groups before treatment (P> 0.05). The total effective rate was 88.6% after treatment with batroxobin, which was significantly better than the conventional treatment group The total efficiency (64.1%), the difference was statistically significant (P <0.05). Conclusion Conventional treatment based on the addition of batroxobin thrombolytic therapy can relieve intravascular thrombotic occlusion factors, for all-frequency sudden deafness has a significant effect, it is worth promoting.