目的:建立小鼠流感性肺炎模型,明确呼吸道流感病毒感染过程中是否存在特异性的肠道病理损伤,并探讨了其在“肺与大肠相表里”研究中的应用。方法:BALB/c小鼠48只随机分为正常组、模型组。模型组给予25μL 50LD50病毒液滴鼻建立流感病毒感染的小鼠肺炎模型,感染后0、3、5、6 d分别取材,HE染色检测肺脏和大肠、小肠、心脏、肾脏和肝脏组织病理结果,血生化检测血清尿素氮(BUN)、谷丙转氨酶(ALT)和谷草转氨酶(AST)水平。结果:流感病毒感染后,模型组小鼠肺组织出现 OBJECTIVE: To establish a murine model of influenza pneumonia and to determine whether there is a specific intestinal pathological injury during the course of respiratory influenza virus infection and to explore its application in the study of “lung and large intestine phase.” Methods: 48 BALB / c mice were randomly divided into normal group and model group. The model group was given intraperitoneal injection of 25μL 50LD50 virus to establish the pneumonia model of influenza virus infection in mice. The model mice were harvested at 0, 3, 5 and 6 days after infection. The pathological results of lung and colon, small intestine, heart, kidney and liver were detected by HE staining. Serum levels of serum urea nitrogen (BUN), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured by blood biochemistry. Results: After influenza virus infection, the model mice lung tissue appeared