利用造血干细胞治疗心脏损伤尤其是由退化、缺血和炎症引起的损伤已被认为是新近发展的重要治疗心脏病变的手段之一。造血干细胞在生理及病理条件下均能归巢于心肌,并能被动员至外周血且参与心脏的自稳态和组织维持。现就造血干细胞在心脏中归巢与分化的机制以及造血干细胞在治疗心脏病变中的应用进行简要综述。 The use of hematopoietic stem cells for the treatment of heart injuries, especially those caused by degeneration, ischemia and inflammation, has been considered as one of the most important recently developed means of treating heart disease. Hematopoietic stem cells can be homed to the myocardium under both physiological and pathological conditions and can be mobilized to peripheral blood and participate in the homeostasis and tissue maintenance of the heart. Now on the hematopoietic stem cell homing and differentiation in the heart of the mechanism and the application of hematopoietic stem cells in the treatment of heart disease are briefly reviewed.