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目的探讨草酸铂(L-OHP)联合察羟基喜树碱(HCPT)治疗晚期消化道肿瘤的毒副作用及近期疗效。方法将本院2010年1月-2013年1月晚期消化道肿瘤患者65例随机分为两组,观察组34例应用L-OHP联合HCPT治疗,对照组31例应用顺铂联合紫杉醇静脉化疗,对比化疗效果及不良反应情况,并计算各组患者1年、3年、5年的生存率。结果观察组总有效率高于对照组,不良反应率和毒副反应级别低于对照组,差异有统计学意义(P<0.05)。两组患者5年生存率无统计学差异(P>0.05),观察组3年生存率显著高于对照组,平均中位生存时间显著优于对照组,差异有统计学意义(P<0.05)。结论晚期消化道肿瘤患者应用L-OHP联合HCPT能有效提高近期生存率,降低不良反应,提高中位生存时间。
Objective To investigate the toxicity and side effect of L-OHP and HCPT in the treatment of advanced gastrointestinal tumors. Methods 65 cases of patients with advanced gastrointestinal cancer from January 2010 to January 2013 were randomly divided into two groups. 34 cases in the observation group were treated with L-OHP combined with HCPT, 31 cases in the control group were treated with cisplatin combined with paclitaxel intravenous chemotherapy, The effects of chemotherapy and adverse reactions were compared, and the survival rates of one, three, and five years in each group were calculated. Results The total effective rate in the observation group was higher than that in the control group, and the adverse reaction rate and toxicity were lower than those in the control group (P <0.05). The 5-year survival rate of the two groups had no statistical difference (P> 0.05). The 3-year survival rate of the observation group was significantly higher than that of the control group, and the mean median survival time was significantly better than that of the control group (P <0.05) . Conclusions The application of L-OHP combined with HCPT in patients with advanced gastrointestinal cancer can effectively improve the short-term survival rate, reduce adverse reactions and increase the median survival time.