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目的：研究吲哚美辛（消炎痛）对幽门螺杆菌（Ｈｐ）感染大鼠的感染状态和溃疡愈合的影响。方法：用乙酸诱导大鼠胃溃疡，５ｄ后接种ＨｐＡＴＣＣ４３５０４菌株，然后每天皮下注射１次吲哚美辛，２周和４周后检查胃内Ｈｐ菌落数、溃疡愈合情况和髓过氧化物酶（ＭＰＯ）水平。结果：吲哚美辛可以抑制Ｈｐ感染大鼠胃内Ｈｐ的生长，增强Ｈｐ引起的溃疡愈合的延缓作用，引起溃疡病灶部位ＭＰＯ活性升高。结论：吲哚美辛抑制Ｈｐ生长和延缓溃疡愈合的作用与它诱导的中性粒细胞浸润有关。
Objective: To study the effect of indomethacin on infection status and ulcer healing in Helicobacter pylori (Hp) -infected rats. Methods: Gastric ulcer was induced in rats with acetic acid. HpATCC43504 strain was inoculated 5 days later. Indomethacin was instilled subcutaneously once a day for 2 weeks. Hp colonies, ulcer healing and myeloperoxidase MPO) level. Results: Indometacin could inhibit the growth of Hp in the stomach of rats infected with Hp, enhance the delayed healing of ulcer caused by Hp, and cause the increase of MPO activity in the ulcer lesion. Conclusion: Indomethacin can inhibit the growth of Hp and delay the healing of ulcer with its induction of neutrophil infiltration.