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目的观察盐酸曲唑酮联合穴位刺激治疗新婚男性早泄的临床效果。方法选取符合早泄诊断标准的新婚男性患者106例为研究对象,随机分为对照组和观察组,每组53例。对照组口服盐酸曲唑酮治疗,观察组在对照组用药基础上加用中频穴位刺激治疗(包括气海、关元、肾腧、三阴交等)治疗。2组治疗8周后进行疗效评价,检测阴道内射精潜伏期(IELT)和中国早泄患者性功能评价量表(CIPE)评分,并进行不良反应发生情况。结果治疗后,观察组总有效率为92.4%,高于对照组的69.8%(P<0.05)。治疗后,2组IELT时间均延长,CIPE-5评分均提高(P<0.05);在IELT改善方面,观察组较对照组效果更明显(P<0.05),在CIPE-5评分方面,2组差异无统计学意义(P>0.05)。2组均未发生严重不良反应。结论曲唑酮联合中频穴位电刺激治疗早泄可显著改善临床疗效,延长射精潜伏时间,提高CIPE评分,显著改善患者性生活质量,安全可靠,值得临床推广应用。
Objective To observe the clinical efficacy of trazodone combined with acupoint stimulation in the treatment of newly married male premature ejaculation. Methods A total of 106 newly married male patients who meet the diagnostic criteria for premature ejaculation were selected as study subjects and randomly divided into control group and observation group with 53 cases in each group. The control group was treated with trazodone hydrochloride orally. The observation group was treated with mid-frequency point stimulation (including Qihai, Guan Yuan, Shenwan, Sanyinjiao etc.) on the basis of the control group. The curative effect of the two groups was evaluated after 8 weeks of treatment. The intravaginal ejaculation latency (IELT) and CIPE score of Chinese patients with premature ejaculation were detected and the incidence of adverse reactions was observed. Results After treatment, the total effective rate in the observation group was 92.4%, which was higher than that in the control group (69.8%, P <0.05). After treatment, the IELT time was prolonged in both groups, and the CIPE-5 scores were all improved (P <0.05). In IELT improvement, the observation group was more effective than the control group (P <0.05) The difference was not statistically significant (P> 0.05). No serious adverse reactions occurred in both groups. Conclusion Trazodone in combination with acupoint electrical stimulation for premature ejaculation can significantly improve the clinical curative effect, prolong the latent time of ejaculation, raise the CIPE score, significantly improve the quality of life of patients, and be safe and reliable. It is worthy of clinical application.