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非可控性炎症可能启动并参与了癌症的发生、发展、浸润转移和抵抗治疗等各个病理过程。研究表明,癌变过程中调控网络的关键节点多与应激、炎症和免疫相关。炎症相关信号通路,尤其是NF-κB通路,在慢性炎症癌变和转移中发挥关键调控作用。在口腔黏膜癌变过程中,上游miRNA基因调控网络发挥了十分关键的作用。以非可控性炎症恶性转化疾病模型—口腔扁平苔藓和口腔黏膜体外多步骤癌变模型为研究对象,针对癌启动、促进和发展过程,确立恶性转化时空调控节点的miRNA和mRNA表达谱型,综合利用医学统计和生物信息学分析技术及整合分析策略,在遗传学和表观遗传学2个层面,动态解析非可控性炎症和癌症之间存在的必然联系,确定恶性转变节点的基本调控网络和癌变的关键因子,无疑能为“抗炎”这一新型癌症治疗模式提供理论依据和有效干预靶点。
Non-controllable inflammation may initiate and participate in various pathological processes such as carcinogenesis, development, invasion and metastasis, and resistance therapy. Studies have shown that the key nodes in the regulatory networks during carcinogenesis are more related to stress, inflammation and immunity. Inflammation-related signaling pathways, especially the NF-κB pathway, play a key regulatory role in carcinogenesis and metastasis of chronic inflammation. In the process of oral mucosal carcinogenesis, the upstream miRNA gene regulation network has played a very crucial role. The model of malignant transformation of non-controllable inflammatory diseases - oral lichen planus and oral mucosa in vitro multi-step carcinogenesis model for the study of cancer initiation, promotion and development of miRNA and mRNA expression profiles of malignant transformation of space-time nodes, the synthesis Using medical statistics and bioinformatics analysis techniques and integrated analysis strategies, we can dynamically analyze the inexorable links between non-controllable inflammation and cancer in genetics and epigenetics, and determine the basic regulatory network of malignant transformation nodes And cancer of the key factors, will undoubtedly provide a theoretical basis and effective intervention targets for the new anti-inflammatory model of cancer treatment.