应用放射免疫法和单光子骨密度测定法测定了１１３例绝经前后妇女的血清骨钙素水平（ＢＧＰ）、尺桡骨平均骨密度（ＢＭＤ），并测定了甲状旁腺激素（ＰＴＨ）、降钙素（ＣＴ）、雌二醇（Ｅ２）等多种骨代谢参数。结果：绝经后妇女血清ＢＧＰ升高，绝经５年内升高最为明显，ＢＭＤ逐渐下降，ＢＧＰ与ＢＭＤ呈正相关，骨转换水平升高。提示绝经后妇女因缺乏雌激素存在骨质丢失。这一过程可能是在多种因素参与下，骨形成和骨吸收之间不平衡所致。 Serum levels of osteocalcin (BGP) and ulnar radius and average bone mineral density (BMD) in 113 premenopausal and postmenopausal women were measured by radioimmunoassay and single photon bone mineral density measurement. PTH, (CT), estradiol (E2) and other bone metabolism parameters. Results: Serum BGP increased in postmenopausal women, with the most obvious increase in 5 years after menopause. The BMD decreased gradually. BGP was positively correlated with BMD and the bone turnover increased. Tip postmenopausal women due to lack of estrogen there is a loss of bone mass. This process may be caused by the imbalance of bone formation and bone resorption with the involvement of many factors.