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目的探讨肺部疾病合并真菌感染患者血浆(1-3)-β-D葡聚糖(BG)水平的动态变化与临床疗效的评价。方法应用MB-80微生物动态快速检测系统及真菌BG检测试剂盒检测87例肺部疾病合并真菌感染患者抗真菌治疗前、后与对照组血浆BG水平及对患者治疗前、后行痰液真菌培养。结果 87例患者抗真菌药物治疗前、治疗1周后、2周后血浆BG水平分别为(162.81±70.03)、(15.89±30.88)、(4.58±7.87)pg/mL,对照组血浆BG水平为(5.62±1.83)pg/mL,治疗前患者血浆BG水平分别与治疗1周后、2周后水平及对照组比较差异有统计学意义(P<0.05);治疗1周后患者血浆BG水平分别与治疗2周后和对照组比较差异有统计学意义(P<0.05)。87例患者抗真菌药物治疗1周后进痰液真菌培养阳性66例,治疗2周后培养阳性9例。结论通过连续监测患者血浆BG水平,结合痰液真菌培养结果及临床症状、肺部阴影情况判断临床抗真菌疗效有一定的临床价值。
Objective To investigate the dynamic changes of plasma levels of (1-3) -β-D-glucan (BG) in patients with pulmonary diseases complicated with fungal infection and evaluate its clinical efficacy. Methods MB-80 microbial rapid detection system and fungal BG detection kit were used to detect 87 cases of pulmonary disease with fungal infection before and after anti-fungal treatment in patients with control group plasma BG levels and sputum fungal culture before and after treatment . Results The levels of plasma BG in two groups were (162.81 ± 70.03), (15.89 ± 30.88) and (4.58 ± 7.87) pg / mL before antifungal treatment and 1 week after treatment, respectively (5.62 ± 1.83) pg / mL respectively. The level of plasma BG in patients before treatment was significantly lower than that in the first week, the second week and the control group (P <0.05) Compared with the control group after 2 weeks of treatment, the difference was statistically significant (P <0.05). One week after antifungal therapy in 87 patients, 66 cases were positive for sputum fungal culture, and 9 cases were positive for culture after 2 weeks of treatment. Conclusion It is of clinical value to judge clinical antifungal efficacy through continuous monitoring of plasma BG levels in patients with sputum fungal culture results and clinical symptoms, lung shadow situation.