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目的探讨盐酸右美托咪定(DEX)在重症监护室(ICU)机械通气患者中的应用效果。方法选取2015年6月—2016年3月安徽医科大学附属六安医院ICU接受机械通气治疗的患者58例,随机将患者分为对照组28例与观察组30例。对照组患者给予常规咪达唑仑镇静镇痛治疗,观察组患者给予DEX镇静镇痛治疗,比较两组患者入ICU 4h(T1)、8h(T2)和12h(T3)心率与平均动脉压水平,并比较两组患者唤醒时间、机械通气持续时间、入住ICU时间及芬太尼使用量,观察两组患者不良反应发生情况。结果观察组患者入ICU后T1、T2、T3时心率、平均动脉压低于对照组,差异有统计学意义(P<0.05)。观察组患者唤醒时间、机械通气持续时间、入住ICU时间短于对照组,芬太尼使用量少于对照组,差异有统计学意义(P<0.05)。两组患者均未出现严重不良反应。结论DEX在ICU机械通气患者中的应用效果确切,具有可唤醒镇静与无呼吸抑制的优点,且不良反应少。
Objective To investigate the effect of dexmedetomidine hydrochloride (DEX) in intensive care unit (ICU) patients with mechanical ventilation. Methods From June 2015 to March 2016, 58 patients who underwent mechanical ventilation in the ICU of Lu’an Hospital Affiliated to Anhui Medical University were randomly divided into control group (28 cases) and observation group (30 cases). Patients in the control group were treated with conventional midazolam sedation and analgesia, and patients in the observation group were given DEX sedation and analgesia. Heart rate and mean arterial pressure were compared between the two groups at 4h (T1), 8h (T2) and 12h (T3) The wake time, the duration of mechanical ventilation, the time of ICU stay and the amount of fentanyl were compared between two groups to observe the adverse reactions of the two groups. Results The heart rate and mean arterial pressure at T1, T2 and T3 in observation group were significantly lower than those in control group (P <0.05). The awakening time, duration of mechanical ventilation, ICU stay in the observation group were shorter than those in the control group, while those in the observation group were less than those in the control group. The difference was statistically significant (P <0.05). No serious adverse reactions occurred in both groups. Conclusion The application of DEX in ICU patients with mechanical ventilation has definite effect, which has the advantages of arousing calm and no respiration, and less adverse reactions.