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ＣＤ２８是Ｔ细胞激活中重要的共刺激分子。为了解Ｂ７－ＣＤ２８共刺激途径在系统性红斑狼疮（ＳＬＥ）中的作用，我们对３０例活动期ＳＬＥ患者外周血Ｔ细胞ＣＤ２８的表达进行了检测，并分析了其激活后凋亡（ａｃｔｉｖａｔｉｏｎ－ｉｎｄｕｃｅｄ ｃｅｌｌ ｄｅａｔｈ，ＡＩＣＤ）情况。结果表明，ＳＬＥ组的ＣＤ２８＋Ｔ细胞低于正常对照组，在抗ＣＤ３单抗刺激后ＣＤ２８＋细胞凋亡率增加。这提示ＳＬＥ中Ｂ７－ＣＤ２８共刺激途径介导的 ＡＩＣＤ可能导致 ＳＬＥ中的Ｔ细胞淋巴细胞贫血症。
CD28 is an important costimulatory molecule in T cell activation. To investigate the role of the B7-CD28 costimulatory pathway in systemic lupus erythematosus (SLE), we detected the expression of CD28 on peripheral blood T cells in 30 active SLE patients and analyzed its activation- induced cell death, AICD). The results showed that CD28 + T cells in SLE group were lower than those in normal control group, and the apoptosis rate of CD28 + cells increased after anti-CD3 mAb stimulation. This suggests that AICD mediated by the B7-CD28 costimulatory pathway in SLE may result in T-cell lymphocytic anemia in SLE.