目的　研究血清基质金属蛋白酶 9(MMP 9)水平、白细胞计数与缺血性脑卒中的梗死灶体积大小以及预后的关系 ,并探讨其潜在的机制。方法　对 12 4名缺血性脑卒中患者在发病后 2 4h抽取肘静脉血 ,用酶联免疫吸附测定法测定MMP 9水平 ,并进行白细胞计数。根据脑卒中患者临床神经功能缺损程度评分标准对患者入院以及出院时进行评分 ,所有患者均进行CT/MRI检查。结果　脑梗死组MMP 9水平及白细胞计数均明显高于腔隙性脑梗死组以及对照组。相关分析结果表明 ,MMP 9水平与预后呈等级正相关 (r =0 .180 ,P =0 .0 4 6 )。白细胞数增高组脑梗死与腔梗构成比、病死率、MMP 9水平明显高于白细胞数正常组 ,而治疗有效率则明显低于白细胞数正常组。结论　脑梗死急性期血清MMP 9水平、白细胞计数可能与脑梗死患者梗死体积大小以及近期预后有密切的关系 Objective To investigate the relationship between serum matrix metalloproteinase 9 (MMP 9) level, white blood cell count (WBC), infarct size, and prognosis in ischemic stroke and to explore its possible mechanism. Methods Twenty - four patients with ischemic stroke were drawn elbow venous blood 24 h after onset of illness. MMP - 9 levels were measured by enzyme - linked immunosorbent assay and white blood cell count was performed. According to the clinical neurological deficit score of stroke patients, patients were scored on admission and discharge, and all patients underwent CT / MRI examination. Results The levels of MMP-9 and leukocyte in cerebral infarction group were significantly higher than those in lacunar infarction group and control group. Correlation analysis showed that there was a positive correlation between MMP-9 level and prognosis (r = 0.80, P = 0.046). The ratio of cerebral infarction to lumen stalks increased with the increase of white blood cell count. The case fatality rate and MMP-9 level were significantly higher than those of the normal white blood cell group, while the effective rate of treatment was significantly lower than that of the normal white blood cell group. Conclusions Serum MMP-9 level and leukocyte count in the acute stage of cerebral infarction may be closely related to the infarct volume and prognosis in patients with cerebral infarction