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目的 探讨抗精神病药 (APD)致静坐不能的临床特征及相关因素。方法 采用临床标准化评定工具对 2 60例精神分裂症住院病人进行 3个月的观察研究。结果 静坐不能发生率为 2 3 5 % ,不伴焦虑症状者为 3 6 1%。发生时间在治疗后 4周内及下午、晚上较多 (P <0 0 1) ;静坐不能组的APD治疗剂量、治疗前BPRS评分较高 (P <0 0 5或P <0 0 1) ;静坐不能评分与各临床变量无显著相关性。单发组与伴发组临床资料有一定差异 ;心得安治疗静坐不能效果良好 ,单发组疗效优于伴发组 (P <0 0 1) ,而对其他锥体外系症状疗效差。结论 静坐不能发生受生物时间、精神症状、药物及个体素质等因素的影响。静坐不能多数应归属于急性锥体外系反应 ,部分可能为药源性精神副反应的运动不宁状态。作者提出了静坐不能不同类别与处理措施。
Objective To investigate the clinical features and related factors of antipsychotics (APD) Methods Two hundred and sixty schizophrenic inpatients were observed for 3 months by clinical standardized assessment tools. Results The incidence of sit-in incapacity was 23.5%, and those without anxiety symptoms were 361%. (P <0.01); APD treatment dose of sedentary group, the BPRS score before treatment was higher (P <0.05 or P <0.01); the incidence of APD was higher in 4 weeks after treatment and in the afternoon and evening (P <0.01) There was no significant correlation between sit-in score and clinical variables. There was a difference in the clinical data between single-group and concomitant group. The treatment with ST-A was superior to the single-group (P <0.01), while the other extrapyramidal symptoms were not effective. Conclusions Sit-ups can not occur due to biological time, psychiatric symptoms, medications and individual qualities. Most of the rest should not be attributed to the reaction of the extrapyramidal system, some may be drug-induced mental side effects of restless state. The authors suggest that meditation can not be different categories and treatment measures.