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目的探讨女性乳腺癌患者保乳术后瘤床加量大分割放疗的毒性、乳房美容及治疗效果。方法收集行保乳术后大分割放疗的14例女性乳腺癌患者,年龄26~61岁,中位年龄44.5岁。全乳腺放疗剂量40.5Gy/(15次·21 d),瘤床高危区加量至46.5 Gy/(16次·22 d)(其中3 Gy/次于全乳腺放疗结束后追加完成)。结果 13例患者表现为Ⅰ度急性放射性皮炎,1例发生程度较轻的Ⅱ度急性放射性皮炎;亚急性及远期皮肤毒性均为Ⅰ度。所有患者心肺毒性均为0度,乳房美容效果为佳/良级。中位随访23.3个月,未见局部复发。结论女性乳腺癌患者保乳术后瘤床加量大分割放疗具有良好的耐受性和乳房美容效果,初步疗效优。
Objective To investigate the toxicity, breast cosmetic and therapeutic effects of large fractionated radiotherapy in breast cancer patients after breast-conserving surgery. Methods A total of 14 female breast cancer patients undergoing major fractionated radiotherapy after breast conserving surgery were enrolled. The median age was 44.5 years. The total breast dose of 40.5 Gy / (15 times · 21 days), high dose of tumor bed dose to 46.5 Gy / (16 times · 22 days) (of which 3 Gy / subtotal mammary gland after the end of radiotherapy completed). Results Thirteen patients showed grade Ⅰ acute radiodermatitis and one case had mild grade Ⅱ acute radiodermatitis. Subacute and long-term dermal toxicity were grade Ⅰ. Cardiopulmonary toxicity was 0 degrees in all patients, breast cosmetic results better / good grade. The median follow-up of 23.3 months, no local recurrence. Conclusion Female patients with breast cancer after breast conserving surgery plus a large fractionated radiotherapy with good tolerance and breast cosmetic results, the initial effect is excellent.