论文部分内容阅读
目的:通过观察中药复方制剂脂脉宁对酒精性脂肪肝(AFL)大鼠血清TNF-α和IL-8含量的影响,以探讨其治疗AFL的可能作用机制。方法:采用喂饲高脂饲料配合白酒灌胃法复制AFL大鼠模型,实验分组为正常组、模型组、阳性药(东宝肝泰片)对照组和脂脉宁高、低剂量组。观察各组大鼠血清TC、TG、AST、ALT、TNFα-和IL-8的含量以及肝组织病理形态学变化的影响。结果:脂脉宁能明显降低实验大鼠TC、TG、AST、ALT、TNFα和IL-8的含量,改善肝脏病理损害。结论:脂脉宁具有改善肝功能,减少TNF-α和IL-8的分泌,调节免疫的作用,能防治AFL。
OBJECTIVE: To observe the effect of Zhijinning, a traditional Chinese drug preparation, on serum TNF-α and IL-8 levels in alcoholic fatty liver disease (AFL) rats and to explore its possible mechanism of action in treating AFL. Methods: AFL rat model was reproduced by feeding high-fat diet and white wine gavage. The experimental group was divided into normal group, model group, positive control (Dongbaogan Tai Pian) control group and Zhiganning high and low dose groups. The levels of TC, TG, AST, ALT, TNFα- and IL-8 in serum of rats in each group were observed, as well as the changes of liver histopathology. Results: Zhijinning can significantly reduce the content of TC, TG, AST, ALT, TNFα and IL-8 and improve the pathological damage of liver in experimental rats. Conclusion: Zhijinning can improve liver function, reduce the secretion of TNF-α and IL-8, regulate the immune function and prevent and treat AFL.