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gp330和受体相关蛋白(RAP)是Heymann肾炎的病理性抗原,其分子上存在着病理性抗原决定簇。循环中抗gp330和抗RAP抗体与肾小球上皮细胞表面抗原结合原位形成免疫复合物,在抗Crry和/或抗CD59的参与下激活补体,形成C5b-9膜攻击复合物,导致肾小球上皮损伤、肾小球基底膜损害,最终形成蛋白尿。在主动型Heymann肾炎发病中,细胞免疫导致的肾小球上皮细胞损害及基底膜的破坏可能是主要机制
gp330 and receptor-associated protein (RAP) is a pathological antigen of Heymann nephritis, the molecular presence of pathological epitopes. Cyclic anti-gp330 and anti-RAP antibodies form immune complexes in situ with the surface antigen binding of glomerular epithelial cells, activating complement with the involvement of anti-Crry and / or anti-CD59 to form the C5b-9 membrane attack complex leading to renal Ball epithelial injury, glomerular basement membrane damage, the final formation of proteinuria. In the active Heymann nephritis incidence, glomerular epithelial cell damage caused by cellular immunity and the destruction of the basement membrane may be the main mechanism