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载脂蛋白E(ApoE)是血浆主要载脂蛋白之一,主要由肝脏合成和代谢,它具有多种生物学活性,不仅与血脂代谢和动脉粥样硬化密切相关,而且还参与神经细胞的修复和免疫调节,与正常老化、病理老化中的认知功能缺损相关联,对人类智能有一定的影响。近年来的研究发现,ApoE不同基因型对脂质代谢、动脉硬化及冠状动脉粥样硬化性心脏病有影响,同时与中枢神经系统疾病如脑梗死、阿尔茨海默病、多发性硬化等,以及精神分裂症有关。本文就此方面的研究进行简要综述,阐述了ApoE基因的作用,对这些疾病的防治有重要意义。
Apolipoprotein E (ApoE) is one of the major apolipoproteins in plasma. It is mainly synthesized and metabolized by the liver. It has various biological activities and is not only closely related to blood lipid metabolism and atherosclerosis, but also involved in the repair of nerve cells And immune regulation, associated with cognitive impairment in normal aging and pathological aging, have some impact on human intelligence. In recent years, the study found that different genotypes of ApoE on lipid metabolism, arteriosclerosis and coronary atherosclerotic heart disease have an impact, while with central nervous system diseases such as cerebral infarction, Alzheimer’s disease, multiple sclerosis, etc., And schizophrenia related. In this paper, a brief review of the study, elaborated the role of ApoE gene, prevention and treatment of these diseases is of great significance.