本文合成了 L-苯丙氨酸修饰 β-环糊精 (1 ) ,应用荧光光谱分光光度滴定方法测定了 2 5℃下 1与几种脂肪醇在磷酸缓冲溶液 (p H7.2 0 )中形成包结络合物的稳定常数 ,从主 -客体间的尺寸 /形状适合、客体分子的刚性及疏水性、疏水相互作用、范德华力等方面考察了主体对客体的分子识别 ,并与 L -色氨酸修饰β-环糊精的分子识别进行了比较。 In this paper, β-cyclodextrin (1) modified by L-phenylalanine was synthesized. The fluorescence spectrophotometric titration method was used to determine the effect of 1 and several fatty alcohols in phosphate buffer solution (p H7.2 0) The stability constants of the inclusion complexes were formed. The molecular recognition of the host was investigated from the aspect of the size / shape fit between the host - guest, the rigidity and hydrophobicity of the guest molecules, the hydrophobic interaction and Van der Waals forces. The molecular recognition of tryptophan-modified β-cyclodextrin was compared.