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目的了解克拉玛依市区体检人群的脂肪肝、尿酸水平等代谢组分与肾脏功能的相关性。旨在早期保护肝肾功能及预防心、脑血管事件。方法对克拉玛依市区6532例体检人员的资料进行分析。结果脂肪肝患病率18.67%,男(28.33%)、女(7.85%)差异有统计学意义(P<0.01)。脂肪肝组血清三酰甘油、血清总胆固醇、血糖、血尿酸水平均明显升高,差异有统计学意义(P<0.05)。按肌酐水平分析,在肌酐正常和异常增高2组人群中,血糖、血尿酸和谷氨酰转肽酶、低密度脂蛋白水平差异有统计学意义(P<0.05)。在尿酸水平处于正常生理范围高值的情况下,它的保护性更高。结论脂肪肝男性患病率高于女性,且与血尿酸水平异常升高、血脂异常等及肾功能损伤具有相关性,在生理状态下随着尿酸水平的升高,尿酸对肾脏功能尚有保护作用。
Objective To understand the correlation between the metabolic components such as fatty liver and uric acid in the urban population in Karamay city and renal function. To protect liver and kidney function early and prevent cardiovascular and cerebrovascular events. Methods The data of 6532 medical staff in Karamay urban area were analyzed. Results The prevalence of fatty liver was 18.67%, male (28.33%), female (7.85%), the difference was statistically significant (P <0.01). Serum triglyceride, serum total cholesterol, blood glucose and serum uric acid in fatty liver group were significantly increased, the difference was statistically significant (P <0.05). Analyzed by creatinine, blood glucose, serum uric acid, glutamyl transpeptidase, and low density lipoprotein were significantly different in two groups with normal and abnormal creatinine (P <0.05). It is more protective when uric acid is at a high normal physiological range. Conclusions The prevalence of fatty liver is higher in males than in females, and is related to the abnormal increase of serum uric acid level, dyslipidemia and renal dysfunction. Uric acid has protection to renal function under the physiological state with the increase of uric acid level effect.