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目的:观察全反式维甲酸(ATRA)和ATRA加小剂量三尖杉酯碱(LDH)治疗急性早幼粒细胞白血病(APL)的疗效。方法:66例急性早幼粒细胞白血病患者分成A、B两组:A组29例单用ATRA,B组37例ATRA和LDH合用。结果:完全缓解率A组为82.7％,B组为94.4％。两组完全缓解时间分别为39.50d±7.43d和24.12d±3.60d(P<0.001)。高白细胞综合征发生率分别为34.4％和5.5％(P<0.05)。结论:ATRA和LDH联合治疗APL可提高完全缓解率,缩短完全缓解时间,减少高白细胞综合征发生率,降低早期死亡率,因此本方法治疗APL有推广应用价值。
Objective: To observe the efficacy of all-trans retinoic acid (ATRA) and ATRA plus a small dose of harringtonine (LDH) in the treatment of acute promyelocytic leukemia (APL). Methods: Sixty-six patients with acute promyelocytic leukemia were divided into two groups: A group (n = 29) with ATRA alone and B group (n = 37) with ATRA combined with LDH. Results: The complete remission rate was 82.7% in group A and 94.4% in group B. The complete remission time was 39.50d ± 7.43d and 24.12d ± 3.60d, respectively (P <0.001). The incidence of high white blood cell syndrome were 34.4% and 5.5%, respectively (P <0.05). Conclusion: ATRA and LDH combined treatment of APL can improve the complete remission rate, shorten the time to complete remission, reduce the incidence of high white blood cell syndrome and reduce the early mortality rate, so the method of treatment of APL has the value of promotion and application.