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进行性多灶性脑白质病(PML)是一种少见的中枢神经系统脱髓鞘病变。随着人类免疫缺陷病毒的全球蔓延,现在进行性多灶性脑白质病更多的见于艾滋病(HIV/AIDS)病人。该病起病隐匿,病死率高,且目前尚无有效的治疗方法。该文综述了近年来HIV/AIDS相关进行性多灶性脑白质病的研究进展,以期有助于临床认识与治疗本病。
Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease of the central nervous system. With the global spread of human immunodeficiency virus, progressive multifocal leukoencephalopathy is now seen more in HIV / AIDS patients. The disease occult onset, high mortality, and there is no effective treatment. This review summarizes the progress of HIV / AIDS-related progressive multifocal leukoencephalopathy in recent years in order to help clinical understanding and treatment of this disease.