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目的观察老年2型糖尿病患者使用二甲双胍的安全性。方法2001年1月至2008年12月在本院并使用二甲双胍治疗的120例老年糖尿病患者的临床资料进行回顾性分析,观察二甲双胍治疗前后,空腹血糖、餐后血糖、糖化血红蛋白(HbALC)的变化。结果本组老年糖尿病患者服用二甲双胍治疗时间6个月～21年,单用二甲双胍治疗22例(18.3%),联合其他口服降糖药者61例(51%),联合胰岛素治疗者37例(30.7%)均能有效降低空腹及餐后血糖和HbALC水平,观察有无乳酸中毒发生。结论老年糖尿病患者合理应用二甲双胍治疗即可达到良好的降血糖效果也较为安全,年龄并非二甲双胍治疗的禁忌证。治疗注意掌握适应证和治疗剂量,在一些风险人群应监测血乳酸水平。
Objective To observe the safety of metformin in elderly type 2 diabetic patients. Methods The clinical data of 120 elderly diabetic patients treated with metformin in our hospital from January 2001 to December 2008 were retrospectively analyzed. The changes of fasting blood glucose, postprandial blood glucose, HbAlc in patients with metformin before and after metformin treatment were observed. . Results The elderly diabetic patients were treated with metformin for 6 months to 21 years. Metformin alone was used in 22 patients (18.3%), in combination with other oral hypoglycemic agents in 61 patients (51%), combined with insulin therapy in 37 patients (30.7 %) Can effectively reduce fasting and postprandial blood glucose and HbALC levels, to observe the occurrence of lactic acidosis. Conclusion Elderly patients with diabetes mellitus can be treated with metformin to achieve good hypoglycemic effect is relatively safe, age is not a contraindication to metformin treatment. Treatment attention to indications and treatment dose, in some risk groups should monitor blood lactate levels.