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目的分析自拟宣肺升降方对慢性阻塞性肺疾病急性发作期(AECOPD)伴炎性反应综合征患者凝血的影响。方法将240例AECOPD伴炎性反应综合征患者按照入院先后以随机数字表法将患者分为研究组与对照组各120例。对照组采用综合处理。研究组在对照组治疗基础上加用自拟宣肺升降方。治疗前及治疗后第5天晨空腹静脉血检测2组血浆中纤维蛋白原(Fbg)、D-二聚体以及血清中内皮素-1(ET-1)、细胞黏附分子-1(ICAM-1)水平,估测第一秒用力呼气容积占用力肺活量的比值(FEV1/FVC)、第一秒用力呼气容积占预计值百分比(FEV1%)变化,并进行比较。结果治疗前2组Fbg、D-二聚体、ET-1、ICAM-1、FEV1/FVC和FEV1(%)差异无统计学意义(P>0.05)。治疗后,2组Fbg、D-二聚体、ET-1、ICAM-1水平均低于治疗前,FEV1/FVC和FEV1(%)水平高于治疗前,且研究组优于对照组,差异均有统计学意义(P<0.05)。结论自拟宣肺升降方可显著改善AECOPD伴炎性反应综合征患者肺功能,分析其机制与自拟宣肺升降方改善患者体内血凝状态,从而减轻AECOPD患者肺动脉压力有关。
Objective To analyze the influence of Xuanfei Shengqian Recipe on coagulation in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) accompanied by inflammatory response syndrome. Methods A total of 240 AECOPD patients with inflammatory reaction syndrome were randomly divided into study group and control group according to the random number table method. Control group using integrated treatment. Study group in the control group based on the addition of self-Xuanfei lifts. Plasma fasting fibrinogen (Fbg), D-dimer and serum levels of endothelin-1 (ET-1), cell adhesion molecule-1 (ICAM- 1), FEV 1 / FVC, FEV 1% of the first second forced expiratory volume were estimated and compared. Results There was no significant difference in Fbg, D-dimer, ET-1, ICAM-1, FEV1 / FVC and FEV1 between the two groups before treatment (P> 0.05). After treatment, the levels of Fbg, D-dimer, ET-1 and ICAM-1 in two groups were lower than those before treatment, and the levels of FEV1 / FVC and FEV1 (%) were higher in the study group than in the control group All were statistically significant (P <0.05). Conclusions Self-made Xuanfei Lifting can significantly improve lung function in AECOPD patients with inflammatory response syndrome, and its mechanism is related to the self-made Xuanfei Lifting and Falling Recipe in improving the blood coagulation status in patients with pulmonary hypertension in patients with AECOPD.