为了探究力竭性运动与大鼠心肌在致病机理和关联性的功能分析,试验随机选取Wistar大鼠72只,并将选取的样本进行随机性分类,分为安静对照组、力竭性运动组,数量分别为12只、60只。按照不同的恢复时间将力竭性运动组分为运动后即刻组、3 h组、6 h组、24 h组、48 h组、96 h组,每组10只。结果表明:力竭性运动后血清一氧化氮(NO)水平均有所升高(P<0.05),运动后即刻开始升高,3 h组达到高峰,此后出现降低一直持续到24 h组,而48 h组再度上升,96 h组下降,数据表现出明显的周期性;血清丙二醛(MDA)含量分析显示,样本运动前后数据变化较小;运动后血清超氧化物歧化酶(SOD)活性无明显变化(P>0.05);与运动前相比,运动后Mn-SOD活性显著升高(P<0.05),运动后Cu Zn-SOD活性显著降低(P<0.05)。运动后不同时间心肌形态有不同程度的变化,心电图会出现ST-T段改变,且呈现2个周期性改变。说明力竭性运动后导致心肌组织处于即刻性和延迟性损伤,NO与即刻性损伤和延迟性损伤有密切关系,SOD和MDA存在一定相关性。 In order to explore the functional analysis of exhaustive exercise and myocardial pathogenesis in rats and its correlation, we randomly selected 72 Wistar rats, and randomized the selected samples into quiet control group, exhaustive exercise group Group, the number was 12, 60. According to different recovery time, the exhaustive exercise group was divided into 3 groups: immediate exercise group, 3 h group, 6 h group, 24 h group, 48 h group and 96 h group, with 10 rats in each group. The results showed that the level of serum nitric oxide (NO) increased after exhaustive exercise (P <0.05), increased immediately after exercise, peaked at 3 h, then decreased to 24 h after exhaustive exercise, However, the levels of serum SOD and MDA in the 48 h group increased again and decreased in 96 h group. The data showed obvious periodicity. The content of malondialdehyde (MDA) in the serum showed little change before and after exercise. The activity of Mn-SOD was significantly increased (P <0.05) and the activity of Cu-SOD was significantly lower after exercise than that before exercise (P <0.05). At different times after exercise, the myocardial morphological changes in varying degrees, ECG changes will appear ST-T segment, and showed two cyclical changes. It shows that exhaustive exercise leads to immediate and delayed myocardial injury, NO is closely related to immediate injury and delayed injury, and SOD and MDA are related to each other.