目的　观察铅对电压依赖性外向延迟整流钾通道的作用。方法　运用膜片钳技术 ,在急性分离的成年大鼠背根神经节细胞 (DRGs)上进行。结果　记录到DRG神经元外向延迟整流K+ 电流 (IK) ,并观察到铅对IK 的明显影响 ,1 0、2 0、4 0、8 0 μmol/LPb2 + 作用后 ,IK 平均分别减少 (8 6±0 8) %、(38 6± 6 2 ) %、(6 3 0± 5 1) %和 (89 0± 8 8) %。Pb2 + 作用起效甚快 ,在Pb2 + 充分作用后 ,以普通外液冲洗 ,IK 可得到不同程度的恢复。结论　铅在较高浓度可阻断成年大鼠背根神经元电压依赖性外向延迟整流钾通道 ,这种阻断作用是剂量依赖性的、可逆的 Objective To observe the effect of lead on voltage-dependent outward delayed rectifier potassium channel. Methods Patch clamp techniques were performed on acutely isolated rat dorsal root ganglion cells (DRGs). RESULTS: Extrinsic delayed rectifier K + current (IK) was recorded in DRG neurons, and the significant effect of lead on IK was observed. After I 0, 20, 40 and 80 μmol / L LP2 + treatment, IK decreased ± 0 8%, 38 6 ± 6 2%, 6 3 0 ± 5 1% and 89 0 ± 8 8%, respectively. Pb2 + has a rapid onset of action. After sufficient action of Pb2 +, it is rinsed with ordinary external fluid and IK can be restored to various degrees. Conclusion Lead at a higher concentration can block the voltage-dependent outward delayed rectifier potassium channels in dorsal root neurons of adult rats. The blocking effect is dose-dependent and reversible