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目的 了解系统性红斑狼疮 (SLE)治疗结局的影响因素。方法 采用描述性预后研究 ,通过单因素和多因素logistic回归对 14 33例系统性红斑狼疮患者的临床特征、实验室检查与疾病的预后进行分析。结果 单因素分析显示发热、心动过速、呼吸加快、收缩压升高和舒张压升高、抗核抗体、抗ds DNA抗体 ,补体C3降低、C反应蛋白阳性、SLE复发、起病急、胸膜炎、神经系统异常和并发器质性脑综合征与SLE预后在统计学上差异有显著性。多因素logistic回归分析显示与SLE患者的治疗结局有关的检验指标为心动过速、舒张压升高、补体C3降低、抗ds DNA抗体、SLE复发、并发器质性脑综合征 ,其OR值分别为 2 .2 8、2 .34、2 .4 2、2 .4 7、1.98和 5 .5 6。结论 SLE患者的临床表现及实验室检查结果多样 ,心动过速、舒张压升高、补体C3降低、抗ds DNA抗体阳性、SLE复发和并发器质性脑综合征对SLE的治疗结果有一定的不利影响 ,但对SLE预后的判断需综合考虑。
Objective To investigate the influencing factors of the treatment outcome of systemic lupus erythematosus (SLE). Methods Using descriptive prognostic analysis, the clinical characteristics, laboratory tests and prognosis of 1433 patients with systemic lupus erythematosus were analyzed by single factor and multivariate logistic regression. Results Univariate analysis showed that fever, tachycardia, accelerated breathing, elevated systolic blood pressure and diastolic blood pressure increased. Antinuclear antibodies, anti-ds DNA antibodies, reduced complement C3, C-reactive protein, recurrent SLE, , Neurological abnormalities and complicated organic brain syndrome and SLE prognosis were statistically significant differences. Multivariate logistic regression analysis showed that the test indicators related to the treatment outcome of SLE patients were tachycardia, elevated diastolic blood pressure, decreased complement C3, anti-dsDNA antibody, SLE recurrence, and organic brain syndrome. The OR values were 2 2 8,2 .34 2 .4 2,2 4 47,1.98 and 5 .5 6. Conclusion The clinical manifestations and laboratory tests of patients with SLE are diverse. Tachycardia, elevated diastolic blood pressure, decreased complement C3, anti-dsDNA antibody positive, SLE recurrence and complicated organic brain syndrome have some therapeutic effect on SLE Adverse effects, but the judgment of SLE prognosis must be considered.