低氧诱导因子-1(hypoxia induc ib le factor-1,H IF-1)和H IF-2是调节氧稳态的核心转录因子,在机体的病理和生理过程中起关键作用,在肿瘤形成中也发挥非常重要的作用。H IF-1和H IF-2是由α和β两个亚基组成的异源二聚体,其活性主要由H IF-α亚基决定。虽然H IF-1α和H IF-2α在分子结构、DNA结合活性和转录活性方面有许多相似性,但两者在具体的目的基因表达调控上又明显不同,从而各自在许多与低氧有关的病理生理过程中发挥特异的作用。 HIF-1 and HIF-2, as the core transcription factors that regulate the homeostasis of oxygen, play a key role in the pathological and physiological processes of the body. In the process of tumor formation Also play a very important role. H IF-1 and H IF-2 are heterodimers composed of two α and β subunits whose activity is mainly determined by the H IF-α subunit. Although there are many similarities in molecular structure, DNA binding activity and transcriptional activity between HIF-1α and HIF-2α, both of them are obviously different in the regulation of the specific gene of interest so that they are involved in many hypoxia-related Pathophysiology plays a specific role.