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目的:探讨墓头回提取液对荷U14宫颈癌小鼠实体瘤生长的作用和血清VEGF的影响。方法:采用U14移植性小鼠宫颈癌模型,墓头回提取液按所含浸膏量分别为1500、750和375mg/(kg·d)3个剂量组用于U14荷瘤小鼠模型试验;用ELISA法检测各组动物血清VEGF含量变化。结果:墓头回提取液高、中剂量组及顺铂阳性对照组能降低宫颈癌荷瘤小鼠血清中VEGF的含量。结论:墓头回提取液具有抑制肿瘤生长的作用。
Objective: To investigate the effect of tomb extract on the growth of solid tumors in U14 cervical cancer mice and the effect of serum VEGF. Methods: U14 transplanted mouse cervical cancer model was used. The extract of Tombouilla was used to test U14 tumor-bearing mice in three doses of 1500, 750 and 375 mg / (kg · d) Serum VEGF levels in each group were detected by ELISA. Results: The high, medium and low cisplatin-positive control group of Tauchow extract could decrease the content of VEGF in the serum of cervical cancer-bearing mice. Conclusion: The head tomb extract has the effect of inhibiting tumor growth.