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了解沙利度胺治疗多发性骨髓瘤时发生的不良反应。方法:观察32例多发性骨髓瘤应用沙利度胺期间不良反应的发生情况。结果:沙利度胺不良反应的总发生率为94％,消化系统不良反应87.5％,神经精神系统不良反应84.4％,其它不良反应有窦缓、逸搏心率、药物热、皮疹、水肿等。结论:不良反应以消化及神经系统的症状最常见,停药及减量可减少不良反应的发生,出现不良反应的原因与剂量大小及个体差异有关。
Learn about the side effects of thalidomide in treating multiple myeloma. Methods: The incidence of adverse reactions was observed in 32 patients with multiple myeloma treated with thalidomide. Results: The overall incidence of adverse reactions of thalidomide was 94%, adverse reactions of the digestive system were 87.5%, 84.4% were adverse reactions of neuropsychiatric system. Other adverse reactions included sinus delay, escape heart rate, drug fever, skin rashes and edema. Conclusion: Adverse reactions to digestive and nervous system symptoms are the most common. Drug withdrawal and weight loss can reduce the incidence of adverse reactions. The causes of adverse reactions are related to dose size and individual differences.